A man, uprooting from his life in San Fransisco, takes on a rider on his long drive towards Denver, but finds they don't get along.

A driver in West Virginia suddenly encounters an older man standing in the middle of the road and agrees to take him to his destination. Though the driver judges the man for his weary appearance, the older man reveals to the driver his life's regrets.

While driving from Massachusetts to Wyoming for his brother's funeral, a man finds himself meeting every obstacle imaginable, from being rear-ended to getting stuck in a sudden snowstorm.

A young couple hitchhiking to a commune accept drugs from the trucker driving them. High and hallucinating, they must appease the unpredictable trucker while keeping him at a safe distance.

A man leaves his family in NYC to look for a job out West. During the trip, he helps an injured young boy, sleeps with a waitress, and considers leaving his family for good.

When a man has an altercation on the road with a motorcyclist, he tries to forget about it — until he stops at a gas station and finds the motorcyclist's bike in the parking lot.

A family going for a ride in their new car makes a wrong turn onto an incredibly trafficked freeway leading to an unknown place.

On an East Coast highway, four truckers get in a terrible car accident. Unable to rescue the injured driver, one of the truckers fires his gun in a mercy killing, then must suffer the consequences.

A drug-addled hitchhiker takes a ride with a family. Their car gets in a collision, and the hitchhiker wanders around the scene, unwilling and unable to help.

On a long taxicab ride to Idaho, a man bonds with his driver.