A bus filled with passengers from different walks of life begins its long journey. Everyone has different problems assailing their otherwise ordinary lives, but as the bus rolls along, these issues begin to be resolved for each through the unwitting actions of the others.

A man, uprooting from his life in San Fransisco, takes on a rider on his long drive towards Denver, but finds they don't get along.

A man flies back to the country of his birth and reckons with people and places he longer seems to know.

On a long taxicab ride to Idaho, a man bonds with his driver.

A driver in West Virginia suddenly encounters an older man standing in the middle of the road and agrees to take him to his destination. Though the driver judges the man for his weary appearance, the older man reveals to the driver his life's regrets.

A man leaves his family in NYC to look for a job out West. During the trip, he helps an injured young boy, sleeps with a waitress, and considers leaving his family for good.

Two college students hitch a ride back home to Charleston with a pair of travelers who bet they could make the 135 mile-long trip in 2 hours flat. When the ride turns to be more terrifying than fun, the students fear it may be too late to bail.

A man reflects on his countless journeys on Greyhounds—and the woman he hoped to see at his destinations.

A gas station worker develops a friendship with a diner waitress that edges towards intimacy, but another man in her life prevents them from getting any closer.

A crotchety old woman gets off at the wrong bus stop and, to her dismay, is stuck in a town she's never heard of with strangers whose behavior is bizarre and disconcerting.