A bus filled with passengers from different walks of life begins its long journey. Everyone has different problems assailing their otherwise ordinary lives, but as the bus rolls along, these issues begin to be resolved for each through the unwitting actions of the others.

A man meets a frail homeless girl at a train station. The brief interaction leaves him questioning and doubting himself and the nature of compassion.

When a bus is taken hostage, a woman comes to terms with her death.

A young man invites a tourist to his favorite London café and recounts the strangest affair he’d ever had with a woman he picked up there; a woman who challenged and changed him. A young, beguiling man picks a tourist out of a group and invites him to see the real sites of London, not the tired and disappointing spectacles. He takes the tourist to the Café de Paris, an old but grand establishment with the promise of dancing and young ladies. The man admonishes his companion to loosen up, stay and drink, and while they wait for the evening to unfold the man begins a story.

When a woman finds her purse stolen, she retraces the steps of her eventful day only to realize that the encounters, and her life as a whole, are empty and purposeless.

A New Yorker riding the subway to meet her lover suddenly finds herself exiting onto an unfamiliar platform that furls out into an alternate version of New York, unable to find her way home.

After her possessions begin to disappear from her apartment, a woman suspects that her adoring new husband is not who she thought he was.

After her lover abandons her for someone else, a woman plummets to her death on a Monday night, only to return as a ghostly presence who finds none of her problems solved.

After a man finds out his wife is having an affair from a butt dial, he invites strangers walking on the street into his apartment to chat and ease his turmoil.

Passengers remain on a bus that may never reach its destination.