A woman addicted to narcotics works as a waitress and fixes up her apartment in hopes of getting back her son from foster care after throwing him against a wall.

A young teen in Southern California, after several months of living on the streets, tries to rebuild her life. She suddenly disappears after six months of sobriety, leaving her family to yet again wonder if she has relapsed and returned to live on the streets again.

An embittered man's stepbrother has been incarcerated for drug possession. When the man visits him in prison, he learns that his stepbrother has been set up.

As he flushes three decades of narcotics out of his system, an Arkansas man recalls a traumatic hunting trip into the woods with his father and his friends. In this memory, he finds the roots of both his addiction and his identity.

When the father of her baby overdoses, a young mother with a crippling drug addiction hits rock bottom much faster than she thought possible. All the while, she must take care of her son and figure out how to survive.

In a lab nicknamed "Spiderhead," experiments involving mind-altering drugs are run on convicted murderers. After he sleeps with two female prisoners, a male prisoner is forced to decide which woman he would like to give a pain-inducing drug.

A homeless man in the Southern US is accused of a crime he didn't commit. As he goes through the conviction process, he learns about the ugly truths of the American justice system and its need to punish outcasts.

A series of interconnected vignettes and characters explores themes of race, incarceration, family, heartbreak, and love.

After his cellmate and sexual partner leaves for parole, an inmate forms a new relationship and moves into a room with three other men, but he struggles to adapt to this new life, which involves a whole new set of expectations.

When a sober woman in her thirties meets a strange man involved in high-profile drug deals, she is horrified to learn that he has followed her for weeks. Eventually, the woman goes against her better judgement and begins to date him after he promises her a life of luxury and comfort.