A young teen in Southern California, after several months of living on the streets, tries to rebuild her life. She suddenly disappears after six months of sobriety, leaving her family to yet again wonder if she has relapsed and returned to live on the streets again.

A woman addicted to narcotics works as a waitress and fixes up her apartment in hopes of getting back her son from foster care after throwing him against a wall.

A counselor breaks his sobriety streak after several meetings with a frustrating client. After arguing with his wife while drunk, the counselor begins to feel murderous and must fight his violent urges to earn back her trust.

Fresh out of rehab, a young man returns to New York City searching for girl he used to know, finding ghosts from his past along the way.

A mother reflects on her past struggles with addiction.

An alcoholic hospital janitor with a murky, dark family history meets a capricious woman with even worse substance abuse problems than him. As they get sober and build a relationship, a series of misfortunes at work drives him to confront his painful past and his understanding of death.

A Native American man in Arizona is abandoned by his family on account of his alcoholism, leaving him to work with a local White ranch owner on the condition that he remain sober. Over the course of a year working there, he remains sober, and his wife considers moving back with their son, but his old friends and old habits return to tempt him towards addiction.

When a sober woman in her thirties meets a strange man involved in high-profile drug deals, she is horrified to learn that he has followed her for weeks. Eventually, the woman goes against her better judgement and begins to date him after he promises her a life of luxury and comfort.

As he flushes three decades of narcotics out of his system, an Arkansas man recalls a traumatic hunting trip into the woods with his father and his friends. In this memory, he finds the roots of both his addiction and his identity.

In the first personal plural, a psychiatric ward patient describes their day-to-day routines and thoughts while their life slowly becomes easier.