A young teen in Southern California, after several months of living on the streets, tries to rebuild her life. She suddenly disappears after six months of sobriety, leaving her family to yet again wonder if she has relapsed and returned to live on the streets again.

When a friend from his drug-dealing past shows up unannounced, a filmographer who lives in the suburbs of Long Island must reckon with how to preserve his suburban fantasy while he tries to save his friend from their former dealer.

A woman addicted to narcotics works as a waitress and fixes up her apartment in hopes of getting back her son from foster care after throwing him against a wall.

As he flushes three decades of narcotics out of his system, an Arkansas man recalls a traumatic hunting trip into the woods with his father and his friends. In this memory, he finds the roots of both his addiction and his identity.

When a sober woman in her thirties meets a strange man involved in high-profile drug deals, she is horrified to learn that he has followed her for weeks. Eventually, the woman goes against her better judgement and begins to date him after he promises her a life of luxury and comfort.

When the father of her baby overdoses, a young mother with a crippling drug addiction hits rock bottom much faster than she thought possible. All the while, she must take care of her son and figure out how to survive.

A Native American man in Arizona is abandoned by his family on account of his alcoholism, leaving him to work with a local White ranch owner on the condition that he remain sober. Over the course of a year working there, he remains sober, and his wife considers moving back with their son, but his old friends and old habits return to tempt him towards addiction.

A slice of grim parts of life

A drug counselor grows anxious about leaving her career in New York City and moving upstate, where she will dedicate herself to her partner and daughter.

In the 1990s, a 19-year-old aspiring actor-turned-construction worker develops an affinity for crack cocaine, making him doubt the promise of his future.