A woman posts an ad in a magazine for people positive for HIV and goes on dates with one degrading man after another, looking for someone to love.

When a man living in New York in the 1980s contracts HIV/AIDS, his friends constantly visit him in the hospital, leading to tears, drama, and questions of mortality and survival.

As he naviagtes his own sobriety, a man finds out that his best friend of twenty years has two months to live due to HIV/AIDS. With help from the dying friend's lover, the man helps prepare his friend for a final bronchoscopy.

A nurse finds that she cannot shake her discomfort with her daughter's sexuality after her daughter comes out as a lesbian. After she attends to a patient who is dying of AIDS, she comes to the realization that her homophobia contradicts her role as caregiver and mother.

A plague targeting Black citizens sweeps the nation causing chaos and despair.

In downtown Houston, a teenage boy hustles for an older pimp and navigates an increasingly intimate relationship with one of his clients. He also keeps the pimp’s HIV diagnosis a secret from the rest of their crew.

In the 1990s, as a mother watches her thirty-three-year old son slowly die from AIDS, she grows closer to him than she ever has before.

In a town full of people with tuberculosis, the healthy young daughter of a nurse is teased by two wealthy but frail sisters. When she is caught lying about the cause of her father's death, the girl must figure out how to be proud of who she is.

In the far future, HIV cases skyrocket in South Africa, and chemists develop an expensive new drug that must be taken annually by those with the disease. When clinics start raising prices, a man attempts to steal the drug for his friend, only to be confronted with an ugly truth about the industry.

In the 1980s, a private investigator and ex-cop visits his close friend, a gay man dying from AIDS, who tasks him with hunting and killing the man who murdered his sister twenty years ago. But when the investigator finds the murderer, he's already close to death.