A woman posts an ad in a magazine for people positive for HIV and goes on dates with one degrading man after another, looking for someone to love.

When a man living in New York in the 1980s contracts HIV/AIDS, his friends constantly visit him in the hospital, leading to tears, drama, and questions of mortality and survival.

As he naviagtes his own sobriety, a man finds out that his best friend of twenty years has two months to live due to HIV/AIDS. With help from the dying friend's lover, the man helps prepare his friend for a final bronchoscopy.

A nurse finds that she cannot shake her discomfort with her daughter's sexuality after her daughter comes out as a lesbian. After she attends to a patient who is dying of AIDS, she comes to the realization that her homophobia contradicts her role as caregiver and mother.

In the far future, HIV cases skyrocket in South Africa, and chemists develop an expensive new drug that must be taken annually by those with the disease. When clinics start raising prices, a man attempts to steal the drug for his friend, only to be confronted with an ugly truth about the industry.

In the 1990s, as a mother watches her thirty-three-year old son slowly die from AIDS, she grows closer to him than she ever has before.

In 2018, a pedestrian on the New York City’s Lower East Side witnesses a young Black couple in love, prompting a consideration about the storytelling, hope, and Nelson Mandela.

Consumed by the memory of his larger-than-life roommate who recently passed away from AIDS, a grieving man working at an art gallery reflects on life.

When a lesbian Cuban woman moves to the United States, she finds her hopes of romantic relationships, familial reconciliation, and prosperity threatened by an onslaught of mysterious medical concerns.

To fulfill her mother’s dying wish, a woman tries to find the right man to have sex with just once.