After a trial injection of an experimental drug into a group of monkeys, an observer watches the various participants’ unusual and often deadly responses.

How far will people go for a hit of prehistoric ecstasy?

In a lab nicknamed "Spiderhead," experiments involving mind-altering drugs are run on convicted murderers. After he sleeps with two female prisoners, a male prisoner is forced to decide which woman he would like to give a pain-inducing drug.

In the near future, an investigative journalist interviews several key players in the rise of a genetic enhancement drug that has made predominantly white Americans Black.

A young girl performs the twice-daily ritual of giving her grandmother her insulin shot as her uncle schemes to steal the syringes for his own drug use. At the same time, her mother wounds her by placing all of her faith in her brilliant cousin to lift himself out of poverty and into happiness, as if the family is not happy already.

A grieving sheriff takes it upon himself to battle the opium epidemic in his area after losing his nephew and wife to a drug dealer known only as the "hellbender."