A man is traveling across I-90 towards New York with his dog, Minerva, when he hears a horn off in the distance.

The man has a flashback to a time when he raced sled dogs for a living in Alaska. In those days, he knew another sled dog racer named Steven Graham—a former literature professor who was trying to reinvent himself after losing his job.

During one race, the 1992 Iditarod, Steven fell prey to "The Hunt," a hellish killing ritual carried out by demon-like creatures who have the task of hunting someone. News of the race says that Stephen took a wrong turn and ended up freezing. But the man from Alaska knew the report was fake because he'd witnessed what happened to Steven. One evening during the race, the Alaskan man came across Steven and his dogs murdered and mutilated on the trail. When the man got there, a huntsman and his wolf-like men were surrounding Stephen. The man from Alaska shot at them and escaped in a snowstorm.

After the flashback, driving along the highway, the man stops at a diner. Steven enters, looking as alive as ever. He sits down and tells the man from Alaska that he is going to be hunted and the only rule is that he ought to run.

After that, the man goes to counseling. His wife leaves him, and his literary agent robs him of his savings. His colleague, Jack Fort, theorizes that the man from Alaska’s bad luck has something to do with what happened in 92’. The man from Alaska had called his friend Jack before the incident at the diner. They'd talk about the legend of the Hunt and how the Hunt was now after the man from Alaska. The man from Alaska is reminded that any prey of the Hunt is subject to damnation.

Jack, who sounds sick on the phone, offers to help and encourages the man to head to his place in Lamprey Aisle. Later that night, the man from Alaska packs his belongings into his truck and heads out. The pack chases after him and speaks to him through the radio, but the man manages to lose them along the way.

Once the man gets to Lamprey Aisle, Jack welcomes him to his cabin. Jack reveals that he is dying of cancer but wants to help his old friend. He says his plan is to fight using various weapons that he has at the cabin. Jack feels it is likely that they will die but at least they will go down fighting. Jack explains the eerie and mysterious history of Lamprey Aisle. He gives him a tour and shows him monoliths, which he thinks are the reason why he has cancer.

The Hunt arrives the following afternoon. The pair are drinking when they hear the Horn of the Hunt, which blows out all the glass and wood in the cabin. The man from Alaska, Minerva the dog, and Jack put up a fight. In the chaos, Steven, the Huntsman, slits Jack’s throat, and the dog is killed. The fight continues until the man from Alaska ignites a piece of dynamite as Steven is stabbing him in the chest. He wakes up paralyzed and close to death. Steven is sprawled across from him. He gets up and goes to see if the man from Alaska is dead when Jack staggers over, somehow alive, and shoots Steven.

The man from Alaska dies. But he wakes up petting his dog in a room that has a hole in the ceiling. Jack is there, healed and muscular. He explains that Steven is dead, again. The man from Alaska realizes that his dog has red eyes and jagged teeth. He sees that Jack is wearing the Huntsman’s hat. The only reason they are alive is that they are all now Huntsmen. Jack tells him to get up and that they are going after a man called Stanley.