Enrique and his bandmates, Sofia and Sebastian, are traveling through Mexico on tour when their management convinces them to fly from Mexico City to Matamoros for a photoshoot for their next album. Having heard of legends from the area regarding Santa Muerte, the saint of death, the rock band treks out to rural Mexico to pose with a statue of her found in the city. After their photoshoot, the band is on their way out when the van tires pop and their driver gets shot. Dragged out of the van, they're abducted and taken to a secret location where they stay huddled with other abductees in a church. Looking around, Enrique sees a Santa Muerte statue with a scythe, standing fifteen feet tall, made of a skeleton so realistic that he must remind himself that it must be fake. By speaking with the other prisoners, the group discovers that everyone is there because they committed a perceived offense against this gang. A man with his face painted like a skull collects one person at a time, severing their appendages and cauterizing them, then sacrificing their blood and bodies for Santa Muerte. One day, the Skull takes two prisoners, Sebastian and another man. After a conversation with Sebastian, he forces him to cut the man up and sacrifice him. The next day, the Skull collects Enrique, telling him that though Sebastian is the front man, Enrique is the brains of the operation because he holds the indigenous knowledge in his blood. Skull questions him about his most recent album, investigating how someone who's never killed could understand a primal knowledge that he's learned through sacrifice. Bringing out an ancient relic of obsidian, he tells Enrique that it needs blood, for which they will sacrifice a priest being held. Instead, Enrique cuts himself, using his own blood to catalyze a reaction with the relic that causes supernatural visions to appear in the obsidian. Before succumbing to blood loss, Enrique sees the Santa Muerte statue move her scythe and cut the priest in half. Waking up with stitches, Enrique finds the make-shift prison abandoned, save for Sofia and Sebastian, who'd been left behind when the gang fled. Planning to walk somewhere nearby with cellphone service, the trio exits the church to find the fifteen-foot Santa Muerte outside, swinging her scythe and exacting her destiny.