Gwen Bramble wakes up one night to discover that her breasts (nicknamed George and Gracie) have detached from her body and run away. She follows them to a night club where they dance with other dismembered body parts. One night, Gwen rediscovers the award-winning nude statue she made in high school, back when she was an aspiring sculptor. When her classmates realized that the statue was a self-portrait, she was mercilessly teased, prompting her to give up sculpture forever. Gwen's breasts start running away more often, even when she's in public. She learns that her mother suffered from the same condition, and that her mother's breasts never came back. Her mother urges Gwen to lock her breasts away and save herself from further embarrassment. Instead, Gwen begins sexually experimenting with her detached breasts, which seems to improve their relationship with her. One night, they come back home with a detached penis. At an office party, George detaches and runs away, leading Gwen to be publicly humiliated in front of her coworkers. Gwen decides to put George and Gracie away in a box for good. They try to run away, and Gwen accidentally breaks her nude self-portrait while chasing them. Gwen gets out some clay for the first time since high school and lets her emotions guide her in sculpting a "Still Life with Boobs." Gwen's attractive coworker, Frank, comes to her apartment to retrieve his lost penis. Gwen and Frank bond and kiss.