Jeff is a convicted murderer who is part of a drug experimentation study. A man named Abnesti gives Jeff and a female prisoner, Heather, a drug which makes them find each other incredibly attractive when they previously didn't. Jeff and Heather have sex on the couch, and Abnesti observes them through a one-way mirror. Abnesti then gives them another drug to make them feel normally about one another. Abnesti repeats this process with Jeff and another female prisoner, Rachel. Jeff feels sad that the love he felt in both cases was manipulated and not real. Abnesti takes Jeff to the control room, deemed "Spiderhead" and asks him to pick between Rachel and Heather, one of whom Abnesti will give an incredibly painful drug called Darkenfloxx. Jeff cannot decide, so Abnesti says neither of the women will be given the drug and tells Jeff that he has helped to solve world problems through his participation in this study. Now, he says, humans have the ability to tone affection and love up or down as needed, which could end wars or cure heartbreak. Jeff is placed in a room with a guy named Rogan. Jeff realizes Heather has had sex with both himself and Rogan while under the influence of the love drug and is now being asked to decide which one of the men will receive the Darkenfloxx. Neither of the men receive it, and this same process repeats as Rachel makes the same decision as Heather. Jeff is put in a room with Keith, and finds out that Keith has also had sex with Heather and Rachel. Over the PA, Abnesti is angry with Jeff because he messed with the experimental design integrity through his communication with the other study participants. The next day, Abnesti tells Jeff that his inability to decide whom to give Darkenfloxx to didn't convince his superiors that Jeff has no residual feelings of love for either woman. Instead, Heather will be given Darkenfloxx, and Jeff will be given drugs for eloquence and truthfulness and have to watch and narrate his feelings. Near the end of the time period, Heather kills herself. Abnesti tells Jeff he must repeat this process with Rachel, and gives Jeff Rachel's file to read. Rachel murdered three people. Jeff remembers that he murdered someone with a brick in a fight and his mother paid for him to be in this lab rather than real prison. He refuses to help give Rachel the Darkenfloxx. Abnesti wants to give Jeff a drug to force him to agree, but due to the drug's classification, he needs to get approval. Abnesti leaves, and Jeff uses Abnesti's remote to give Darkenfloxx to himself — he would rather die than murder Rachel.