A teenage girl is diagnosed with a rare disease that physically compels her to move to a city and protect it as her memory and mark on the world slowly fade away. In the city, she finds a ghost of temptation from her past that she may not be strong enough to resist.

In Baltimore in the late 1800s, a child named Benjamin Button is born with the appearance and demeanor of a 70-year-old man. As time progresses, Benjamin ages backward, moving from elderly fragility to youthful exuberance, challenging the natural course of life.