An African woman who works for a wealthy movie director must survive his questionable whims when a deadly pandemic forces them to quarantine in his mansion.

Tiny Pelican Island is one of the few parts of the world still free from the deadly gray pox in 2080 - save for their own patient zero, the plague doctor's six-year-old niece. In order to save her family and her island, the doctor must join the cutthroat race to find a cure.